![]() Nanotechnology offers opportunities to re-explore the biological properties of already known antimicrobial com- pounds by manipulating their size to alter the effect. People who become infec- ted with drug-resistant microorganisms usually spend more time in the hospital and require a form of treatment that uses two or three different antibiotics and is less effective, more toxic, and more expensive (Webb et al. Keywords Drug-resistant bacteria Silver nanoparticles Silver resistance Broad-spectrum agent Bactericidal agent Nanobiotechnology Introduction Drug-resistant bacteria are emerging pathogens whose resistance profiles present a major challenge for containing their spread and their impact on human health.Ĭurrently, over 70 of bacterial nosocomial infections in the United States are resistant to one or more of the antibiotics tradi- tionally used to eliminate them. Our data suggest that silver nanoparticles are effective broad- spectrum biocides against a variety of drug-resistant bacte- ria, which makes them a potential candidate for use in pharmaceutical products and medical devices that may help to prevent the transmission of drug-resistant pathogens in different clinical environments. Through a KirbyBauer test, it was shown that silver nanoparticles general mechanism of bactericidal action is based on inhi- bition of cell wall synthesis, protein synthesis mediated by the 30s ribosomal subunit, and nucleic acid synthesis. Hence, we challenged dif- ferent drug-resistant pathogens of clinical importance (multidrug-resistant Pseudomonas aeruginosa, ampicillin- resistant Escherichia coli O157:H7 and erythromycin- resistant Streptococcus pyogenes) with a suspension of silver nanoparticles.īy means of a luciferase-based assay, it was determined that silver nanoparticles (1) inactivate a panel of drug-resistant and drug-susceptible bacteria (Gram positive and Gram negative), (2) exert their antibacterial activity through a bactericidal rather than bacteriostatic mechanism, and (3) inhibit the bacterial growth rate from the time of first contact between the bacteria and the nanopar- ticles.Īdditionally, strains with a resistant phenotype to silver nanoparticle were developed and used to explore the bactericidal mode of action of silver nanoparticles. The antibacterial activity of silver nanoparticles against some drug-resistant bacteria has been established, but further investigation is needed to determine whether these particles could be an option for the treatment and prevention of drug- resistant microbial infections. Liliana Model Torrent Serial Twofold DilutionsĪbstract Infections caused by drug-resistant microor- ganisms result in significant increases in mortality, morbidity, and cost related to prolonged treatments. ![]()
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